Final answer:
NADH produced in the cytoplasm yields fewer ATP because it cannot easily enter the mitochondria, resulting in less ATP being produced.
Step-by-step explanation:
NADH produced in the cytoplasm yields fewer ATP because it cannot easily enter the mitochondria where most of ATP is produced. Instead, NADH in the cytoplasm is oxidized by the enzyme lactate dehydrogenase, which does not yield ATP. This results in less ATP being produced from NADH in the cytoplasm compared to NADH in the mitochondria.