Final answer:
The leading killer of natives in the Americas during the Age of Exploration was European diseases.
Step-by-step explanation:
The leading killer of natives in the Americas during the Age of Exploration was European diseases. When Europeans arrived in the Americas, they brought with them diseases such as smallpox, measles, and influenza. These diseases were highly contagious and the native populations had no immunity to them, resulting in devastating pandemics that wiped out a significant portion of the native population.
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