Question

What was a major U.S. route from Missouri to the Northwest in the 19th century?

Answer 1

A major U.S. route from Missouri to the Northwest was the Oregon Trail.

The Oregon Trail was roughly 2,100 miles, and it spread from Independence, Missouri, all the way to Oregon City, Oregon.

Thousands of American Pioneers used this route in the mid 1800's.

They used this route to emigrate west.