George Mason of Virginia also known as "The father of the bill of rights" refused to sign the constitution even though he was among the 55 founders who wrote the U.S constitution.
He refused to sign it because it did not end the slave trade and also did not place enough limits on the federal government's power.
When the constitution was made official, he led effort that insisted that in the very first sitting or session of congress, there should be amendments put in place to restrict the powers of the new federal government.