Question

Which type of chromosome rearrangement results in the fusion of the long arms of two nonhomologous chromosomes to produce a larger chromosome and a net reduction in chromosome number?

Answer 1

Below are the choices that can be found from other sources:

Robertsonian translocation
Pericentric inversion
Unbalanced translocation
Reciprocal balanced translocation

The answer is Robertsonian translocation. Robertsonian translocation (ROB) is a rare form of chromosomal rearrangement that, in humans, occurs in the five acrocentric chromosome pairs, namely 13, 14, 15, 21 and 22. Other translocations occur but do not lead to a viable fetus.