There should be options to choose from with this question. I found them elsewhere.
A) Nicotine
B) Caffeine
C) Heroin
D) Marijuana
The answer is heroin. Heroin use can cause damage to many organs with your kidneys and liver being two. Heroin can be quite destructive to the body in ways that the body unfortunately may never recover from. Significant damage to the liver and kidneys is irreparable and in some cases transplants might be needed or having to take certain types of medication to keep them from failing completely.