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Imagine a situation in which the number of urea leak channels increased dramatically in the ascending limb of the loop of Henle. What could be one likely consequence of this situation?

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User Guanfei
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1 Answer

4 votes
The choices are: a. The increased solute concentration in the vasa recta would stimulate additional water reabsorption.b. The final urine output would increase greatly because of the increase in ADH-regulated water reabsorptionc. Aldosterone-regulated Na+ activity would increase dramatically to stablize the osmotic concentration gradient. d. The concentration gradient of the renal medulla would remain unaffected.
Answer: c. Aldosterone-regulated Na+ activity would increase dramatically to stablize the osmotic concentration gradient.
Due to higher concentration of urea, mechanisms will be put into place in order to achieve equilibrium like ionic activity. In the Loop of Henle, its primary function is to produce highly concentrated urine with little water. Permeability to water is very low to none at all in the ascending limb of Loop of Henle so a and b are incorrect.
answered
User Shubham Kanodia
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