Interstitial fibrosis and glomeruli tubular atrophy are pathological effects of hypertension on kidneys. This is especially as a result of hyalinization that results in sclerosis to the glomeruli which may ultimately lead to kidney failure if unmanaged. The hyaline accumulate in the nephron tubules resulting in protein in urine. The plaque build up in the kidneys, as a result, causes glomerular ischemia