Collagenase is produced by several species of Clostridium, facilitates the spread of gas gangrene. And toxins are produced and secreted by actively growing cells, may be found in foods but are usually inactivated by cooking, the host typically responds by producing antibodies called antitoxin, may be toxic in very tiny amounts, may be produced by gram negative or gram positive bacteria; examples include tetanus toxin, cholera toxin, and staphyloccal enterotoxin.