Question

Post-synaptic nmda receptors detect the coincidence of pre-synaptic ___________ release and post-synaptic membrane depolarization caused by activation of __________________ receptors.

Answer 1

Presynaptic release of glutamate and Post synaptic Depolarization caused by AMPA receptor activation at the same AND neighboring synapses (to release Mg2+),lead to strengthening of synapses: activation of NMDA > Ca2+ influx > activate signaling pathway that leafy to long lasting changes in signaling strength.