Portals of entry are the sites where micro-organisms can enter a host and reproduce, causing diseases or infections. There are various portals of entry in the human body. This can include the skin, our mucous membranes, and even our respiratory and gastrointestinal tracts. Portals of exit are where these micro-organisms leave and spread to other individuals. Portals of exit include coughing, sneezing, and some of our bodily fluids.