Question

What kind of metabolic poison would interfere with glycolysis?

Answer 1

Metabolic poisons that interfere with glycolysis include those affecting pyruvate kinase, leading to ATP production failure, and ethylene glycol, which causes metabolic and lactic acidosis.

Step-by-step explanation:

A metabolic poison that could interfere with glycolysis is one that affects enzymes involved in the glycolytic pathway. For instance, compounds that impair the function of pyruvate kinase will hinder the last step of glycolysis, causing a critical reduction in ATP production, especially in red blood cells (RBCs) that rely solely on glycolysis for their energy. Another example is ethylene glycol poisoning, which leads not only to metabolic acidosis due to accumulated glycolic acid but also lactic acidosis, contributing to the inhibition of metabolic pathways.

Answer 2

Generally metabolic poisons affecting glycolysis stop the working of the Krebs Cycle. The poison substitutes for a sugar like glucose but is not able to be metabolized and used like glucose.