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What problem does the chromosome number of various organisms present to evolutionists?

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Chromosome number varies from one organism to another. or example, humans have 46 chromosomes while bacteria have only one chromosome.

The problem associated with the chromosome number of various organisms faced by evolutionists is that with the decrease in the size of an organism, the number of chromosomes also decrease. Thus, it becomes difficult to find and study the chromosomes.
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User Pravesh
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