The mesolimbic and mesocortical dopamine pathways have been implicated in drug abuse and schizophrenia.
Mesolimbic pathways transfer dopamine from the ventral tegmental area to the nucleus accumbens, it includes amygdala and hippocampus. It involved in reward-related cognition and pleasure so that its disorders is an addiction.
Mesocortical pathway it believed in motivational and emotional responses, many investigators said that negative and cognitive symptoms of schizophrenia are connected with hypofunction.