The answer to the question above is GENDER. This is the factor that does not affect one's cardiorespiratory endurance. Based on the options, tobacco, age, and heredity are factors that can affect it. For gender, it does not matter whether someone is male or female. By definition, cardiorespiratory endurance is the how the activities of the heart, lungs, and muscles are measured and assessed. Both genders can improve their cardiorespiratory endurance by doing aerobic exercises.