The antigen-antibody that is deposited in the dermis is known as T-cells. These are protein cells that divide excessively causing the development of thick and calloused skin.
The overproduction of these cells on the dermis area causes the overproduction of collagen fibers on the skin. As the skin pushes its way up to the epridermis, the overproduction of these cells result to the symptoms that are observable for diagnosis.