Answer:
Harper's Ferry, Virginia, was significant in the Antebellum Era because it was the place where John Brown, an abolitionist leader, carried out a raid against a Federal arsenal, with the aim of taking the guns deposited there, give them to several African-American slaves and start a slave revolt in Virginia.
John Brown finally failed to achieve his objectives, the raid was defeated by Robert E. Lee, and he was accused of treason and executed on December 2, 1859.