Question

Describe how a single amino acid substitution causes hemoglobin molecules to stick together. use what you know about the structure of hb and hbs, the properties of glutamic acid and valine, and how hydrophobicity causes molecules to behave in water.

Answer 1

with the additional of a valine, hydrophobic regions appear on the surface of HbS. These hydrophobic molecules gather together in a watery solution. Blood is a watery solution, and the HbS molecules will stick together on their hydrophobic regions.

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