The DNA of a human cell can be cut and rearranged by using Enzymes. To cut DNA into smaller segments, enzyme nucleases are used. They do this by taking the phsophodiester bonds through hydrolysis and catalyzing it. when these enzymes comes into contact with a DNA sequence with a shape that matches a part of the enzyme, called the recognition site, it wraps around the DNA and causes a break in both strands of the molecule.