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Cancer can originate in any area of the body. however, death rates are often highest for those cancers involving organs within the digestive, cardiovascular, and respiratory systems. this is most likely because

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Because they are interior which make it more difficult to notice them and because they are located in vital areas.

Hope it helped!
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User Pabera
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They are often not diagnosed quickly enough and may be harder to treat/ quickly spread
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User Enobrev
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