Four times as much genetic material is present in a cell during prophase I compared to a cell that has competed meiosis II. Prophase I is a phase in the first stage of meiosis (meiosis I). During this phase, chromosomes become visible. cross-over occurs, the nucleolus disappears, the meiotic spindle forms and the nuclear envelope disappears. The genetic materials in prophase I divides into two at the end of meiosis I forming tow daughter cells, which then divides again into two at the end of meiosis II forming four daughter cells.