The correct answer to this open question is the following.
Jamestown had a problem because of its location near a swamp. That problem was poor health.
Jamestown was founded in 1607. It was the first colony to be settled by the English people. The problem was the location near a swamp with a lot of humidity, bacteria, and mosquitos. The water in the river was not as fresh and sometimes it has salty water. In the winter of 1609, people from Jamestown suffered from scarcity and diseases such as scurvy, dysentery, and typhoid. Many people died.