Question

Why is lsd known as a powerful hallucinogenic drug? why is lsd known as a powerful hallucinogenic drug? it activates serotonin receptors in the brain stem, hypothalamus, and limbic system, increasing the concentration of serotonin. lsd destroys serotonin-secreting neurons. it can inhibit the production of serotonin. it binds to serotonin receptors on the post-synaptic membrane, preventing serotonin from binding?

Answer 1

It is because it binds to serotonin receptors on the post-synaptic membrane, preventing serotonin from binding. LSD is structurally similar to serotonin therefore it is able to bind to the serotonin receptors. Actions at the 5-HT2a receptor ( a serotonin receptor) are believed to be responsible for the hallucinogenic effects, though the signaling pathways involved have not been well studied.

Answer 2

The answer is ‘it activates serotonin receptors in the brain stem, hypothalamus, and limbic system, increasing the concentration of serotonin.’ The drug enhances dopamine D2 receptor protomer recognition and signaling of D2–5-HT2A receptor complexes, which may contribute to its psychotic effects. LSD was found to stay bound to both the 5-HT2A and 5-HT2B receptors for an exceptionally long amount of time, which may be responsible for its long duration of action in spite of its relatively short terminal half-life.