Microbes are not the easiest organisms to destroy because they are extremely small. They cant be seen with our naked eyes, you need a microscope to see them. They are difficult to destroy since one can not see them with a naked eye. Microbes are microscopic organisms that cannot be seen by a naked eye. They include fungi, bacteria, viruses, archaea and protists. However, some such as viruses are submicroscopic and thus will need a stronger microscope to see them.