The characteristics that most of the top hit sequences share are; They contain a ribosomal RNA (rRNA) sequence. Additionally, they contain a sequence of an internal transcribed spacer. The ribosome is a cellular machine found in all organism. It serves to convert the instructions found in messenger RNA into the chains of amino-acids that make up proteins. The ribosomes is responsible for the synthesis of proteins. Internal transcribed spacer refers to the spacer DNA situated between the small-subunit ribosomal RNA and large-subunit rRNA genes in the chromosome or the corresponding transcribed region in the polycistronic rRNA precursor transcript.