Question

What will be the effect of a mutation that destroys the ability of poly(a)-binding protein (pabp) to attach to a poly(a) tail?

Answer 1

Mutation is defined as the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

So if mutation destroys the ability of a poly(a) binding protein to attach a poly(a) tail, mRNA would degrade hence disrupt the regulation of mRNA regulation.