TOPOISOMERASE
There are various function of DNA toposisomerase such as:
1.accessing DNA- this happens during transcription and replication, DNA must be unwound for this to happen, Topoisomerase I make a single break to create an access.
2. Removing DNA super coils- Topoisomerase prevents DNA to be supercoiled, this happens during transcription of DNA to RNA
3. Strand breakage- It can introduce single strand breaks that are required for DNA to be exchanged to adjacent chromosomes.