The gene expression of the organism may be affected by the environment. This includes the outside ecosphere where the entire creature and organism are situated or progresses, and also as the organism's interior ecosphere, these consist of the aspects of metabolism and hormones. Even though the structure of genes is unaffected by the environment, the gene expression (how the genes work) will be affected. Factors in the environment like drugs, foods, and toxins may result in some epigenetic changes by changing how the DNA bind by the molecules and the structure change of the proteins that the DNA wraps.