Question: The most famous confederation was the
A. Inca League.
B. Seneca League.
C. Mohawk League.
D. Iroquois League.
Answer: The correct answer is option D, the Iroquois League.
Step-by-step explanation: The Iroquois League was the most famous confederation because the Iroquoian tribes were known to history (to the English) as the Five Nations (the Cayuga, Mohawk, Oneida , Onondaga, and Seneca) and later in 1722 they became known as the Six Nations. This confederation was a historically powerful northeast Native American confederacy. They were known during the colonial years to the French as the Iroquois League, and later as the Iroquois Confederacy.