Long term alcohol abuse affects your liver, as it weakens it (the liver), it is one of our largest organs, which helps your body get rid of waste and fight infections and viruses away. Also, it can lead to death, as your liver is strong, but weaker than other organs, and it is one of your main ones, which means you can't live without it. Drinking a lot of alcohol makes your immune system weaker, and if you drink too much, your liver will become irreparable!
-hope this helps! Xx