The Portuguese made an expedition to Otranto, Italy in 1481 after the conquest of constantinople, the so called "Cruzada Turca". Pope Sixtus IV called for a crusade against the Turks, who occupied Otranto in southern Italy. The Pope's intention was to cross the Adriatic and liberate Vlorë (Valona) as well.
Portugal sent a squadron into Otranto under command of the bishop of Évora, Garcia de Meneses.
By the time the Portuguese reached Naples, the Ottomans had already withdrawn, because the Sultan of the Ottoman Empire, Mehmed II, had died, which made it easier for the Portuguese to have another italian city.