The mitotic spindle is a system put in place by eukaryotic cells to allow chromatid migration during cell division at the prophase stage.
The spindle poisons are a group of anticancer drugs of natural origin characterized by their target, the achromatic spindle that allows chromosomes to migrate during mitosis.
The cancer drug, taxol, interferes with the cells ability to divide, which permanently arrests the cell at the anaphase/metaphase transition.