Question

The amide bond in a protein has a negative ΔG°' of hydrolysis under physiological conditions in the cell. In other words, the peptide bond is thermodynamically unstable, yet proteins are an important component of the cell and do not just fall apart sponstaneously. Why?

Answer 1

The hydrolysis rate is significantly low because the energy of the transition state for hydrolysis is significantly high

Step-by-step explanation:

In the given problem, It was stated that the peptide bond is not stable thermodynamically. Peptide bonds are typically formed between molecules with carboxyl groups and molecules with amino groups. Therefore, it can be inferred that the hydrolysis rate is significantly low because the energy of the transition state for hydrolysis is significantly high.