Question

A mutation in GLUT4 changes the Kt value from 5 mM (wild type) to 3 mM (mutant). The velocity of glucose entry into a mutant cell would be higher than a cell expressing the wild type version at a blood glucose concentration of 5mM.

A) TRUE.
B) FALSE.

Answer 1

Answer: The correct answer is : A) TRUE.

Explanation: GLUT 4 is a protein that transports genetically encoded glucose, is located in adipocytes, skeletal muscle and cardiac muscle, is encoded by a gene on chromosome 17. It has a Km for glucose of 5 mm. When there is no adequate stimulus, most of the GLUT 4 is stored in intracellular vesicles.