Question

p53 is a protein that functions to block the cell cycle if DNA is damaged. If the damage is severe this protein can cause cell death. If there is a mutation in the p53 protein, we might expect what to happen?

Answer 1

Mutation of p53 Gene

Mutation in the p53 protein leads to uncontrolled cell division of tumor cells leading to metastasis of tumor.

Step-by-step explanation:

The p53 gene termed as the tumor protein or TP53 is the gene that encodes the regulatory protein which regulates cell cycle and cell death (apoptosis). Cell cycle and apoptosis are the important factors which prevent proliferation of cells with abnormal DNA. P53 acts as the tumor suppressor and prevents the spread of tumor or cancer. Mutation of p53 gene could be inherited or caused due to chemical, biological, or radiation mutagens. A mutant p53 actually inhibits the action of a natural p53 and thereby inhibits tumor suppression.