Question

Which of the following statements is false?

(A) Mutations in the Kit receptor are seen in familial cancer syndromes
(B) Cytoskeleton-associated proteins are ligands for integrins
(C) Src is a tyrosine kinase
(D) In the JAK-STAT pathway, ligand binding promotes phosphorylation, dimerization and nuclear translocation of transcription activators
(E) In normal cells, RTK dimerization and autophosphorylation (transphosphorylation) are dependent on ligand binding.

Answer 1

(E) in normal cells, RTK dimerization and autophosphorylation (transphosphorylation) are dependent on ligand binding.

Step-by-step explanation:

It has only been recently discovered that there are RTK's that exist as inactive oligomers/dimers even prior ligand binding and that autophosphorylation sites are phosphorylated in a specific order.