Question

The relatively long half-life of lipid soluble hormones (steroid hormones) compared to water soluble hormones is due in part to the way that these hormones are passed into the filtrate from the glomerular capillaries. What's the best explanation for why lipid soluble (steroid) hormones have a relatively long half-life?

Answer 1

The transport protein-hormone complexes of lipid soluble proteins can not cross the filtration membrane of glomerulus.

Step-by-step explanation:

Steroid hormones are water-insoluble (hydrophobic) in nature. Since blood has watery medium, the plasma, the lipid-soluble hormones travel in blood through transport proteins. The transport protein-hormone complexes are too large to cross the filtration membrane of glomerulus. The impermeability of the filtration membrane of glomerulus for protein-hormone complexes increases the half-life of lipid-soluble proteins.