Microbes are found to be problematic for two reasons that they cause infection and sometime these organisms does not respond to antibiotics.
Explanation:
The microbes can cause infections in humans is a problem. Fungi, helminths and protozoans are the major cause of infectious diseases. Resistance to an antibiotic occurs when an ability to defeat drugs created to kill them are developed in a microbe. When a microbe becomes resistant, the antibiotics cannot fight against them and hence they multiply.
Antibiotic resistance is an urgent threat to the health of the public. They become a threat, when a microbe become resistant to antibiotic and it will be very difficult to destroy them. The resistance to antibiotics can cause serious issues like disability or even cause death.