For this case we can translate the sentence as:
They say that the most important of__________is the lipstick.
The options given are:
A. Makeup
B. Hair
C. Appointment
D. Deodorant
It is noted that if we talk about a lipstick, the option that best fits is "Makeup" or "Maquillaje"
Answer:
Dicen que lo mas importante del maquillaje es el lapiz de labios.