Answer:
The change in PH not only effect the shape of enzymes, but it may also change properties the of substrate so that that substrate cannot control to bind the active site and it cannot undergo catalysis.
In general enzymes have a PH optimum. However this optimum is not same for each enzyme.
Step-by-step explanation:
For Example; The enzyme pepsin is most active at an acidic PH, Whereas the enzyme trypsin performs best at slightly alkaline PH. the increase or decrease in PH can change the concentration of ion in a solution