Final answer:
The Aztec and Inca Empires were two major pre-European civilizations in the Americas, with the Inca Empire being the largest pre-Columbian empire and the Aztecs known for their capital city Tenochtitlan.
Step-by-step explanation:
Two major empires that existed in the Americas before the arrival of Europeans were the Aztec Empire and the Inca Empire. The Aztecs were known for their large city of Tenochtitlan and their complex social and political organization. The Inca Empire, on the other hand, was the largest pre-Columbian empire in the Americas, extending across modern-day Peru and beyond, with impressive achievements in architecture, agriculture, and roadway systems.