Question

What type of protein in cAMP signal transduction would be analogous to the phosphatase of the phosphorylation cascade

Answer 1

Phosphodiesterase

Explanation:

Phosphodiesterases are enzymes capable of breaking down phosphodiester bonds. There exist 11 different types (families) of phosphodiesterases that have distinct 3D structures and kinetic properties. Moreover, the cyclic nucleotide phosphodiesterases are a group of enzymes that hydrolyze the phosphodiester bond in nucleotide second messenger molecules such as, for example, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Thus, cyclic nucleotide phosphodiesterases represent a family of enzymes that modulate the localization and duration of nucleotide second messenger signaling.